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KMID : 0043320150380101906
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Archives of Pharmacal Research
2015 Volume.38 No. 10 p.1906 ~ p.1912
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Antibacterial properties of cetyltrimethylammonium bromide-stabilized green silver nanoparticles against methicillin-resistant Staphylococcus aureus
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Jang Hyo-yeong
Lim Soo-Hyeon
Choi Jae-Sue
Park You-Mie
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Abstract
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Silver nanoparticles (AgNPs) were synthesized using Artemisia capillaris extracts in the absence and presence of stabilizers, and the antibacterial activities of the AgNPs against methicillin-resistant Staphylococcus aureus (MRSA) were determined by a minimum inhibitory concentration (MIC) assay. Two stabilizers, cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS), were utilized during the one-step synthesis to increase the colloidal stability of the AgNPs. The extract of A. capillaris was used as a reducing agent to convert silver ions into AgNPs. Sharp surface plasmon resonance bands in the range of 423?426 nm were observed in the UV?Visible spectra of the AgNPs, which indicated that the AgNPs were predominantly spherical shaped. Their average diameter, which ranged from 15.11 to 16.54 nm, was measured from high-resolution transmission electron microscopy images. Remarkably, the CTAB-stabilized AgNPs exhibited greater antibacterial activity (2- to 8-fold increase, MIC 15.6?62.5 μg/mL) against MRSA compared with the extract, AgNPs prepared in the absence of stabilizers, and SDS-stabilized AgNPs. The results indicate that CTAB-stabilized AgNPs prepared using plant extracts as reducing agents are very promising for the development of novel antibacterial agents.
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KEYWORD
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Silver nanoparticles, Artemisia capillaris, Methicillin-resistant Staphylococcus aureus, Cetyltrimethylammonium bromide
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